Lutein Information Bureau
The Story Behind Lutein Eye Health Skin Health Cardiovascular Health Women's Health Where to Find Lutein
LinksSearchFor More Information

Home

Lutein and Cataracts
Frequently Asked Questions
AMD Eye Check
Research Findings
Scientific References

 

Scientific References

Schalch W, Cohn W, Barker FM, Kopcke W, Mellerio J, Bird AC, Robson AG, Fitzke FF, van Kuijk FJ. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (Lutein Xanthophyll Eye Accumulation) study. Arch Biochem Biophys. 2006 Nov 3; [Epub ahead of print]

 

2006

     

Rosenthal JM, Kim J, de Monastario F, Thompson DJ, Bone RA, Landrum JT, de Moura FF, Khachik F, Chen H, Schleicher RL, Ferris FL 3rd, Chew EY. Dose-Ranging Study of Lutein Supplementation in Persons Aged 60 Years or Older. Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5227-5233.

 

2006

     

Mares JA, LaRowe TL, Snodderly DM, Moeller SM, Gruber MJ, Klein ML, Wooten BR, Johnson EJ, Chappell RJ; CAREDS Study Group and Investigators. Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. Am J Clin Nutr. 2006 Nov;84(5):1107-22.

 

2006

     

Khachik F, London E, de Moura FF, Johnson M, Steidl S, Detolla L, Shipley S, Sanchez R, Chen XQ, Flaws J, Lutty G, McLeod S, Fowler B. Chronic Ingestion of (3R,3'R,6'R)-Lutein and (3R,3'R)-Zeaxanthin in the Female Rhesus Macaque. Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5476-5486.

 

2006

     

Khachik F, de Moura FF, Chew EY, Douglass LW, Ferris FL 3rd, Kim J, Thompson DJ. The Effect of Lutein and Zeaxanthin Supplementation on Metabolites of These Carotenoids in the Serum of Persons Aged 60 or Older. Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5234-5242.

 

2006

     

Trevithick-Sutton CC, Foote CS, Collins M, Treithick JR. The retinal carotenoids zeaxanthin and lutein scavenge superoxide and hydroxyl radicals: a chemiluminescence and ESR study. Mol Vis. 2006 Sep 30;12:1127-35.

 

2006

     

Kopsell, DA; Lefsrud, MG; Kopsell, DE; Wenzel, AJ; Gerweck, C; Curran-Celentano, J. Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention. J Agric Food Chem. 2006; 54(21):7998-8005

 

2006

     

Wenzel AJ, Gerweck C, Barbato D, Nicolosi RJ, Handelman GJ, Curran-Celentano J. A 12-wk egg intervention increases serum zeaxanthin and macular pigment optical density in women. J Nutr. 2006 Oct;136(10):2568-73.

 

2006

     

Trumbo PR, Ellwood KC. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am J Clin Nutr. 2006 Nov;84(5):971-4.

 

2006

     

Neelem K, Nolan J, Loane E, Stack J, O’Donovan O, Eong KG, Beatty S. Macular pigment and ocular biometry. Vision Res. 2006; 46(13):2149-56. Epub feb 10.

 

2006

     

Shao, A. and Hathcock, JN. Risk assessment for the carotenoids lutein and lycopene. Regul Toxicol Pharmacol. 2006 Aug;45(3):289-98. Epub 2006 Jun 30.

 

2006

     

Jin XH, Ohgami K, Shiratori K, Suzuki Y, Hirano T, Koyama Y, Yoshida K, Ilieva I, Iseki K, Ohno S. Inhibitory effects of lutein on endotoxin-induced uveitis in lewis rats. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2562-8.

 

2006

     

Delcourt C, Carriere I, Delage M, Barberger-Gateau P, Schalch W, & POLA Study Group. Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study. Invest Ophthalmol Vis Sci. 2006;47:2329–2335

 

2006

     

Bahrami H, Melia M, Dagnelie G. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial. BMC Ophthalmol. 2006 Jun 7;6(1):23

 

2006

     

Kvansakul J, Rodriguez-Carmona M, Edgar DF, Barker FM, Kopcke W, Schalch W, Barbur JL. Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance. Ophthalmic Physiol Opt. 2006 Jul;26(4):362-71.

 

2006

     

Wang M, Tsao R, Zhang S, Dong Z, Yang R, Gong J, Pei Y. Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anti-clastogenicity of lutein from marigold flowers. Food Chem Toxicol. 2006 Apr 25;

 

2006

     

Flood V, Rochtchina E, Wang JJ, Mitchell P, Smith W. Lutein and zeaxanthin dietary intake and age related macular degeneration. Br J Ophthalmol. 2006 Jul;90(7):927-8.

 

2006

     

Guymer RH, Chong EW. Modifiable risk factors for age-related macular degeneration. Med J Aust. 2006 May 1;184(9):455-8.

 

2006

     

Vu H, Robman L, McCarty C, Taylor H and Hodge A. Does dietary lutein and zeaxanthin increase the risk of age related macular degeneration? The Melbourne Visual Impairment Project. Br. J. Ophthalmol. 2006;90;389-390

 

2006

     

Eter N, Krohne TU, Holz FG. New pharmacologic approaches to therapy for age-related macular degeneration. BioDrugs. 2006;20(3):167-79.

 

2006

     

Nolan JM, Stack J, Mellerio J, Godhinio M, O'Donovan O, Neelam K, Beatty S. Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin. Curr Eye Res. 2006 Feb;31(2):199-213

 

2006

     

Choi JS, Kim D, Hong YM, Mizuno S, Joo CK. Inhibition of nNOS and COX-2 expression by lutein in acute retinal ischemia. Nutrition. 2006 Apr 20; [Epub ahead of print]

 

2006

     

Clark R, Herron K, Waters D, and Fernandez M L. Hypo- and hyperresponse to egg cholesterol predicts plasma lutein and b-carotene concentrations in men and women. J. Nutr. 2006;136:601–607

 

2006

     

Rodriguez-Carmona M, Kvansakul J, Harlow J A. The effects of supplementation with lutein and/or zeaxanthin on human macular pigment density and colour vision. Ophthal. Physiol. Opt. 2006 26: 137–147

 

2006

     

Vu H, Robman L, McCarty C, Taylor H and Hodge A. Does dietary lutein and zeaxanthin increase the risk of age related macular degeneration? The Melbourne Visual Impairment Project. Br. J. Ophthalmol. 2006;90;389-390

 

2006

     

de Moura F, HO C, Getachew G, Hickencottom S, Clifford A. Kinetics of 14C distribution after tracer dose of 14C-lutein in an adult woman. Lipids 2005;40(10):1069-1073

 

2005

     

Liew S, Gilbert C, Spector T, Mellerio J, Marshall J, van Kuijk F, Beatty S, Fitzke F, and Hammond C. Heritability of Macular Pigment: A Twin Study. Invest Ophthalmol Vis Sci. 2005;46:4430–4436.

 

2005

     

Ermakov I, Sharifzadeh M, Ermakova M, Gellermann W. Resonance raman detection of carotenoid antioxidants in living human tissue. J. Biomed Optics 064028-18 Nov/Dec 2005 Vol.10_6

 

2005

     

Dasch B, Fuhs A, Schmidt J, Behrens T, Meister A, Wellman J, Fobker M, Pauleikhoff D, Hense HW. Serum levels of macular carotenoids in relation to age-related maculopathy: the Muenster Aging and Retina Study (MARS). Graefes Arch Clin Exp Opthamol. 2005 Oct;243(10):1028-35.

 

2005

     

Santosa, S. and P. J. Jones. Oxidative stress in ocular disease: does lutein play a protective role?" Cmaj 2005; 173(8): 861-2.

 

2005

     

Cardinault N, Abalain JH, Sairafi B, Coudray C, Grolier P, Rambeau M, Carre JL, Mazur A, Rock E. Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients. Clin Chim Acta. 2005 Jul 1;357(1):34-42.

 

2005

     

Ermakov IV, Ermakova MR, Gellermann W. Simple Raman instrument for in vivo detection of macular pigments. Appl Spectrosc. 2005 Jul; 59(7):861-7.

 

2005

     

Johnson EJ, Neuringer M, Russell RM, Schalch W, Snodderly DM. Nutritional manipulation of primate retinas, III: Effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys. Invest Ophthalmol Vis Sci. 2005 Feb;46(2):692-702.

 

2005

     

Leung IY, Sandstrom MM, Zucker CL, Neuringer M, Max Snodderly D. Nutritional manipulation of primate retinas. IV. Effects of n-3 fatty acids, lutein, and zeaxanthin on S-cones and rods in the foveal region. Exp Eye Res. 2005 May 22; [Epub ahead of print]

 

2005

     

Lutein and Zeaxanthin - Monograph. Altern Med Rev. 2005 Jun;10(2):128-135.

 

2005

     

Stringham JM, Hammond BR Jr. Dietary lutein and zeaxanthin: possible effects on visual function. Nutr Rev. 2005 Feb;63(2):59-64. Review.

 

2005

     

Ahmed SS, Lott MN, Marcus DM. The macular xanthophylls. Surv Ophthalmol. 2005 Mar-Apr;50(2):183-93. Review.

 

2005

     

Meyer CH, Sekundo W. Nutritional supplementation to prevent cataract formation. Dev Ophthalmol. 2005;38:103-19.

 

2005

     

Schmidt-Erfurth U. Nutrition and retina. Dev Ophthalmol. 2005;38:120-47.

 

2005

     

Stahl W. Macular carotenoids: lutein and zeaxanthin. Dev Ophthalmol. 2005;38:70-88.

 

2005

     

Chitchumroonchokchai C, Bomser JA, Glamm JE, Failla ML. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. J Nutr. 2004 Dec;134(12):3225-32.

 

2004

     

Miranda M, Muriach M, Johnsen S, Bosch-Morell F, Araiz J, Roma J, Romero FJ. [Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants] Arch Soc Esp Oftalmol. 2004 Jun;79(6):289-94.

 

2004

     

Hogg R, Chakravarthy U. AMD and micronutrient antioxidants. Curr Eye Res. 2004 Dec;29(6):387-401. Review.

 

2004

     

Bartlett H, Eperjesi F. An ideal ocular nutritional supplement? Ophthalmic Physiol Opt. 2004 Jul;24(4):339-49.

 

2004

     

Desmettre T, Lecerf JM, Souied EH. [Nutrition and age-related macular degeneration] J Fr Ophtalmol. 2004 Nov;27(9 Pt 2):3S38-56. French.

 

2004

     

Ribaya-Mercado JD, Blumberg JB. Lutein and zeaxanthin and their potential roles in disease prevention. J Am Coll Nutr. 2004 Dec;23(6 Suppl):567S-87S.

 

2004

     

Bernstein PS, Zhao DY, Sharifzadeh M, Ermakov IV, Gellermann W. Resonance Raman measurement of macular carotenoids in the living human eye. Arch Biochem Biophys. 2004 Oct 15;430(2):163-9.

 

2004

     

Beatty S, Nolan J, Kavanagh H, O'Donovan O. Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin. Arch Biochem Biophys. 2004 Oct;430(1):70-76.

 

2004

     

Ciulla TA, Hammond BR Jr. Macular pigment density and aging, assessed in the normal elderly and those with cataracts and age-related macular degeneration. Am J Ophthalmol. 2004 Oct;138(4):582-7.

 

2004

     

Neuringer M, Sandstrom MM, Johnson EJ, Snodderly DM. Nutritional manipulation of primate retinas, I: Effects of lutein and zeaxanthin supplements on serum and macular pigment in xanthophyll-free rhesus monkeys. Invest Ophthalmol Vis Sci. 2004 Sept;45(9):3234-3243.

 

2004

     

Leung IYF, Sandstrom MM, Zucker CL, Neuringer M, Snodderly DM. Nutritional manipulation of primate retinas, II: Effects of age, n-3 fatty acids, lutein, and zeaxanthin on retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2004 Sept;45(9):3244-3256.

 

2004

     

Schupp C, Olano-Martin E, Gerth C, Morrissey BM, Cross CE, Werner JS. Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Am J Clin Nutr. 2004 Jun;79(6):1045-52.

 

2004

     

Koh HH, Murray IJ, Nolan D, Carden D, Feather J, Beatty S. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. Exp Eye Res. 2004 79:21-27.

 

2004

     

Cho E, Seddon JM, Rosner B, Willett WC, Hankinson SE. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol. 2004 Jun 122:883-892.

 

2004

     

Richer S, Stiles W, Statkute L, Pulido J, Frankowski J, Rudy D, Pei K, Tsipursky, Nyland J. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004 Apr;75(4):216-230.

 

2004

     

Gellermann W, Bernstein PS. Noninvasive detection of macular pigments in the human eye. J Biomed Opt. 2004 Jan;9(1):75-85.

 

2004

     

Blodi BA. Nutritional supplements in the prevention of age-related macular degeneration.Insight. 2004 Jan-Mar;29(1):15-6; quiz 17-8. Review.

 

2004

     

Mitchell P, Smith W, Cumming RG, Flood V, Rochtchina E, Wang JJ. Nutritional factors in the development of age-related eye disease. Asia Pac J Clin Nutr. 2003;12 Suppl:S5.

 

2003

     

Stahl W., Sies H. Antioxidant activity of carotenoids. Mol Aspects Med. 2003 24:345-351.

 

2003

     

Bartlett H, Eperjesi F. A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology. Nutr J. 2003 Oct 10;2(1):12.

 

2003

     

Gale CR, Hall NF, Phillips DI, Martyn CN. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2461-5.

 

2003

     

Semba RD, Dagnelie G. Are lutein and zeaxanthin conditionally essential nutrients for eye health? Med Hypotheses. 2003 Oct;61(4):465-72.

 

2003

     

Granado F, Olmedilla B, Blanco I. Nutritional and clinical relevance of lutein in human health. Br J Nutr. 2003 Sep;90(3):487-502.

 

2003

     

Bartlett H, Eperjesi F. Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials. Ophthalmic Physiol Opt. 2003 Sep;23(5):383-99.

 

2003

     

Sies H, Stahl W. Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin. Int J Vitam Nutr Res. 2003 Mar;73(2):95-100.

 

2003

     

Olmedilla B, Granado F, Blanco I, Vaquero M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Nutrition. 2003 Jan;19(1):21-4.

 

2003

     

Nilsson, S., Sundelin, S., Wihlmark, U., Brunk, U. Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage. Doc. Ophthalmol. 2003 106:13-16.

 

2003

     

Krinsky NI, Landrum JT, and Bone RA. Biological mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu. Rev. Nutr. 2003 23(2):171-201.

 

2003

     

Chopdar A, Chakravarthy U, Verma D. Age related macular degeneration. BMJ. 2003 Mar 1;326(7387):485-8.

 

2003

     

Cardinault N, Gorrand JM, Tyssandier V, Grolier P, Rock E, Borel P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. Exp Gerontol. 2003 May;38(5):573-82.

 

2003

     

Bone RA, Landrum JT, Guerra LH, Ruiz CA. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr. 2003 Apr;133(4):992-8.

 

2003

     

Kang JH, Pasquale LR, Willett W, Rosner B, Egan KM, Faberowski N, Hankinson SE. Antioxidant intake and primary open-angle glaucoma: a prospective study. Am J Epidemiol. 2003 Aug 15;158(4):337-46.

 

2003

     

Mozaffarieh M, Sacu S, Wedrich A. The role of the carotenoids, lutein and zeaxanthin, in protecting againstage-related macular degeneration: A review based on controversial evidence. Nutr J. 2003 Dec 11;2(1):20.

 

2003

     

Broekmans WM, Klopping-Ketelaars IA, Weststrate JA, Tijburg LB, van Poppel G, Vink AA, Berendschot TT, Bots ML, Castenmiller WA, Kardinaal AF. Decreased carotenoid concentrations due to dietary sucrose polyesters do not affect possible markers of disease risk in humans. J Nutr. 2003 Mar;133(3):720-6.

 

2003

     

Zhao DY, Wintch SW, Ermakov IV, Gellermann W, Bernstein PS. Resonance raman measurement of macular carotenoids in retinal, choroidal, and macular dystrophies. Arch Ophthalmol. 2003 Jul;121:967-972.

 

2003

     

Valero MP, Fletcher AE, De Stavola BL, Vioque J, Alepuz VC. Vitamin C is associated with reduced risk of cataract in a Mediterranean population. J Nutr. 2002 Jun;132(6):1299-306.

 

2002

     

Snellen EL, Verbeek AL, Van Den Hoogen GW, Cruysberg JR, Hoyng CB. Neovascular age-related macular degeneration and its relationship to antioxidant intake. Acta Ophthalmol Scand. 2002 Aug;80(4):368-71.

 

2002

     

Bernstein PS, Zhao DY, Wintch SW, Ermakov IV, McClane RW, Gellermann W. Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients. Ophthalmology. 2002 Oct;109(10):1780-7.

 

2002

     

Schweitzer D, Lang GE, Beuermann B, Remsch H, Hammer M, Thamm E, Spraul CW, Lang GK. [Objective determination of optical density of xanthophyll after supplementation of lutein] Ophthalmologe. 2002 Apr;99(4):270-5. German.

 

2002

     

Roberts JE, Kukielczak BM, Hu DN, Miller DS, Bilski P, Sik RH, Motten AG, Chignell CF. The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cells. Photochem Photobiol. 2002 Feb;75(2):184-90.

 

2002

     

Mares-Perlman JA, Millen AE, Ficek TL, Hankinson SE. The body of evidence to support a protective role for lutein and zeaxanthin in delaying chronic disease. Overview. J Nutr. 2002 Mar;132(3):518S-524S.

 

2002

     

Krinsky NI. Possible biologic mechanisms for a protective role of xanthophylls. J Nutr. 2002 Mar;132(3):540S-542S.

 

2002

     

Khachik F, de Moura FF, Zhao DY, Aebischer CP, Bernstein PS. Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3383-92.

 

2002

     

Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB, Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med. 2002 Nov; 227 (10)845-51.

 

2002

     

Johnson EJ. The role of carotenoids in human health. Nutr Clin Care. 2002 Mar-Apr;5(2):56-65.

 

2002

     

Flood V, Smith W, Wang JJ, Manzi F, Webb K, Mitchell P. Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology. 2002 Dec;109(12):2272-8.

 

2002

     

Duncan JL, Aleman TS, Gardner LM, De Castro E, Marks DA, Emmons JM, Bieber ML, Steinberg JD, Bennett J, Stone EM, MacDonald IM, Cideciyan AV, Maguire MG, Jacobson SG. Macular pigment and lutein supplementation in choroideremia. Exp Eye Res. 2002 Mar;74(3):371-81.

 

2002

     

Curran Celentano J, Burke JD, Hammond BR Jr. In vivo assessment of retinal carotenoids: macular pigment detection techniques and their impact on monitoring pigment status. J Nutr. 2002 Mar;132(3):535S-539S.

 

2002

     

Charlton KE. Eating well: ageing gracefully! Asia Pac J Clin Nutr. 2002;11 Suppl 3:S607-17.

 

2002

     

Broekmans WM, Berendschot TT, Klopping-Ketelaars IA, de Vries AJ, Goldbohm RA, Tijburg LB, Kardinaal AF, van Poppel G. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Am J Clin Nutr. 2002 Sep;76(3):595-603.

 

2002

     

Bowen PE, Herbst-Espinosa SM, Hussain EA, Stacewicz-Sapuntzakis M. Esterification does not impair lutein bioavailability in humans. J Nutr. 2002 Dec;132(12):3668-73.

 

2002

     

Bonnefoy M, Drai J, Kostka T. [Antioxidants to slow aging, facts and perspectives] Presse Med. 2002 Jul 27;31(25):1174-84. French.

 

2002

     

Berendschot TT, Broekmans WM, Klopping-Ketelaars IA, Kardinaal AF, Van Poppel G, Van Norren D. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Ophthalmol. 2002 Dec;120(12):1732-7.

 

2002

     

Wooten BR, Hammond BR. Macular pigment: influences on visual acuity and visibility. Prog Retin Eye Res. 2002 Mar;21(2):225-40.

 

2002

     

Shaban H, Richter C. A2E and blue light in the retina: the paradigm of age-related macular degeneration. Biol Chem. 2002 Mar-Apr;383(3-4):537-45.

 

2002

     

Rock CL, Thornquist MD, Neuhouser ML, Kristal AR, Neumark-Sztainer D, Cooper DA, Patterson RE, Cheskin LJ. Diet and lifestyle correlates of lutein in the blood and diet. J Nutr. 2002 Mar;132(3):525S-530S.

 

2002

     

Olmedilla, B., Granado, F., Blance, I. Herrero, C., Vaquero, m., Millan, I. Serum status of carotenoids and tocopherols in patients with age-related cataracts:a case control study. J. Nutr. Health Aging 2002 6:66-68.

 

2002

     

Yemelyanov AY, Katz NB, Bernstein PS. Ligand-binding characterization of xanthophyll carotenoids to solubilized membrane proteins derived from human retina. Exp Eye Res. 2001 Apr;72(4):381-92.

 

2001

     

Taylor A, Hobbs M. 2001 Assessment of nutritional influences on risk for cataract. Nutr. 2001;17:845-857.

 

2001

     

Sundelin SP, Nilsson SE. Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidants. Free Radic Biol Med. 2001 Jul 15;31(2):217-25.

 

2001

     

Pauleikhoff D, van Kuijk FJ, Bird AC. [Macular pigment and age-related macular degeneration] Ophthalmologe. 2001 Jun;98(6):511-9. German.

 

2001

     

Mares-Perlman JA, Fisher AI, Klein R, Palta M, Block G, Millen AE, Wright JD. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. 2001 Mar 1;153(5):424-32.

 

2001

     

Landrum JT, Bone RA. Lutein, zeaxanthin, and the macular pigment. Arch Biochem Biophys. 2001 Jan 1;385(1):28-40. Review.

 

2001

     

Lancrajan I, Diehl HA, Socaciu C, Engelke M, Zorn-Kruppa M. Carotenoid incorporation into natural membranes from artificial carriers: liposomes and beta-cyclodextrins. Chem Phys Lipids. 2001 Jul;112(1):1-10.

 

2001

     

Junghans A, Sies H, Stahl W. Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes. Arch Biochem Biophys. 2001 Jul 15;391(2):160-4.

 

2001

     

Jewell VC, Northrop-Clewes CA, Tubman R, Thurnham DI. Nutritional factors and visual function in premature infants. Proc Nutr Soc. 2001 May;60(2):171-8. Review.

 

2001

     

Jacques PF, Chylack LT Jr, Hankinson SE, Khu PM, Rogers G, Friend J, Tung W, Wolfe JK, Padhye N, Willett WC, Taylor A. Long-term nutrient intake and early age-related nuclear lens opacities. Arch Ophthalmol. 2001 Jul;119(7):1009-19.

 

2001

     

Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001 Apr;6(2):141-66.

 

2001

     

Handelman GJ. The evolving role of carotenoids in human biochemistry. Nutrition. 2001 Oct;17(10):818-22.

 

2001

     

Hammond BR Jr, Wooten BR, Curran-Celentano J. Carotenoids in the retina and lens: possible acute and chronic effects on human visual performance. Arch Biochem Biophys. 2001 Jan 1;385(1):41-6.

 

2001

     

Dachtler M, Glaser T, Kohler K, Albert K. Combined HPLC-MS and HPLC-NMR on-line coupling for the separation and determination of lutein and zeaxanthin stereoisomers in spinach and in retina. Anal Chem. 2001 Feb 1;73(3):667-74.

 

2001

     

Curran-Celentano J, Hammond BR Jr, Ciulla TA, Cooper DA, Pratt LM, Danis RB. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. Am J Clin Nutr. 2001 Dec;74(6):796-802.

 

2001

     

Crabtree DV, Ojima I, Geng X, Adler AJ. Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. Bioorg Med Chem. 2001 Aug;9(8):1967-76.

 

2001

     

Ciulla TA, Curran-Celantano J, Cooper DA, Hammond BR Jr, Danis RP, Pratt LM, Riccardi KA, Filloon TG. Macular pigment optical density in a midwestern sample. Ophthalmology. 2001 Apr;108(4):730-7.

 

2001

     

Bone RA, Landrum JT, Mayne ST, Gomez CM, Tibor SE, Twaroska EE. Macular pigment in donor eyes with and without AMD: a case-control study. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):235-40.

 

2001

     

Bernstein PS, Khachik F, Carvalho LS, Muir GJ, Zhao DY, Katz NB. Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Exp Eye Res. 2001 Mar;72(3):215-23.

 

2001

     

Beatty S, Murray IJ, Henson DB, Carden D, Koh H, Boulton ME. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci. 2001 Feb;42(2):439-46.

 

2001

     

Aleman TS, Duncan JL, Bieber ML, de Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG, Jacobson SG. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Invest Ophthalmol Vis Sci. 2001 Jul;42(8):1873-81.

 

2001

     

Gale CR, Hall NF, Phillips DI, Martyn CN. Plasma antioxidant vitamins and carotenoids and age-related cataract. Ophthalmology. 2001 Nov;108(11):1992-8.

 

2001

     

Sujak A, Okulski W, Gruszecki WI. Organisation of xanthophyll pigments lutein and zeaxanthin in lipid membranes formed with dipalmitoylphosphatidylcholine. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):255-63.

 

2000

     

Rapp LM, Maple SS, Choi JH. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1200-9.

 

2000

     

Moeller SM, Jacques PF, Blumberg JB. The potential role of dietary xanthophylls in cataract and age-related macular degeneration. J Am Coll Nutr. 2000 Oct;19(5 Suppl):522S-527S.

 

2000

     

Dagnelie G, Zorge IS, McDonald TM. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. Optometry. 2000 Mar;71(3):147-64.

 

2000

     

Bone RA, Landrum JT, Dixon Z, Chen Y, Llerena CM. Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp Eye Res. 2000 Sep;71(3):239-45.

 

2000

     

Berendschot TT, Goldbohm RA, Klopping WA, van de Kraats J, van Norel J, van Norren D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest Ophthalmol Vis Sci. 2000 Oct;41(11):3322-6.

 

2000

     

Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000 Sep-Oct;45(2):115-34.

 

2000

     

Sujak A, Gabrielska J, Grudzinski W, Borc R, Mazurek P, Gruszecki WI. Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects. Arch Biochem Biophys. 1999 Nov 15;371(2):301-7.

 

1999

     

Sommerburg OG, Siems WG, Hurst JS, Lewis JW, Kliger DS, van Kuijk FJ. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Curr Eye Res. 1999 Dec;19(6):491-5.

 

1999

     

Siems WG, Sommerburg O, van Kuijk FJ. Lycopene and beta-carotene decompose more rapidly than lutein and zeaxanthin upon exposure to various pro-oxidants in vitro. Biofactors. 1999;10(2-3):105-13.

 

1999

     

Richer S. ARMD--pilot (case series) environmental intervention data. J Am Optom Assoc. 1999 Jan;70(1):24-36.

 

1999

     

Lyle BJ, Mares-Perlman JA, Klein BE, Klein R, Palta M, Bowen PE, Greger JL. Serum carotenoids and tocopherols and incidence of age-related nuclear cataract. Am J Clin Nutr. 1999 Feb;69(2):272-7.

 

1999

     

Lyle BJ, Mares-Perlman JA, Klein BE, Klein R, Greger JL. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study.Am J Epidemiol. 1999 May 1;149(9):801-9.

 

1999

     

Gass JD. Muller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis. Arch Ophthalmol. 1999 Jun;117(6):821-3.

 

1999

     

Chasan-Taber L, Willett WC, Seddon JM, Stampfer MJ, Rosner B, Colditz GA, Speizer FE, Hankinson SE. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr. 1999 Oct;70(4):509-16.

 

1999

     

Brown L, Rimm EB, Seddon JM, Giovannucci EL, Chasan-Taber L, Spiegelman D, Willett WC, Hankinson SE. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr. 1999 Oct;70(4):517-24.

 

1999

     

Beatty S., M. Boulton, H.H. Koh, I.J. Murray (1999). Macular pigment and age related macular degeneration. 83(7):867-77.

 

1999

     

Yeum KJ, Shang FM, Schalch WM, Russell RM, Taylor A. Fat-soluble nutrient concentrations in different layers of human cataractous lens. Curr Eye Res. 1999 Dec;19(6):502-5.

 

1999

     

Pratt S. Dietary prevention of age-related macular degeneration. J Am Optom Assoc. 1999 Jan;70(1):39-47.

 

1999

     

Pelz R, Schmidt-Faber B, Heseker H. [Carotenoid intake in the German National Food Consumption Survey] Z Ernahrungswiss. 1998 Dec;37(4):319-27. German.

 

1998

     

Hammond, B.R., B.R. Wooten, D.M. Snodderly (1998). Preservation of visual sensitivity of older subjets: association with macular pigment density, Invest Ophthalmol Vis Sci 39(2):397-406.

 

1998

     

Chan, C., I. Leung, K.W. Lam, M.O.M. Tso (1998). The occurrence of retinol and carotenoids in human subretinal fluid. Curr Eye Res 17:890-5.

 

1998

     

Bernstein PS, Yoshida MD, Katz NB, McClane RW, Gellermann W. Raman detection of macular carotenoid pigments in intact human retina. Invest Ophthalmol Vis Sci. 1998 Oct;39(11):2003-11.

 

1998

     

Snodderly DM, Shen B, Land RI, Krinsky NI. Dietary manipulation of plasma carotenoid concentrations of squirrel monkeys (Saimiri sciureus). J Nutr. 1997 Jan;127(1):122-9.

 

1997

     

Landrum JT, Bone RA, Kilburn MD. The macular pigment: a possible role in protection from age-related macular degeneration. Adv Pharmacol. 1997;38:537-56.

 

1997

     

Landrum JT, Bone RA, Joa H, Kilburn MD, Moore LL, Sprague KE. A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Exp Eye Res. 1997 Jul;65(1):57-62.

 

1997

     

Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1802-11.

 

1997

     

Hammond BR Jr, Wooten BR, Snodderly DM. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optom Vis Sci. 1997 Jul;74(7):499-504.

 

1997

     

Hammond BR Jr, Johnson EJ, Russell RM, Krinsky NI, Yeum KJ, Edwards RB, Snodderly DM. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1795-801.

 

1997

     

Hammond BR Jr, Fuld K, Snodderly DM. Iris color and macular pigment optical density. Exp Eye Res. 1996 Mar;62(3):293-7.

 

1997

     

Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD, Menendez E, Vidal I, Wang W. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res. 1997 Feb;64(2):211-8.

 

1997

     

Bernstein PS, Balashov NA, Tsong ED, Rando RR. Retinal tubulin binds macular carotenoids. Invest Ophthalmol Vis Sci. 1997 Jan;38(1):167-75.

 

1997

     

Seddon J.M., W.C. Willett, F.E. Speizer, S.E. Hankinson (1996). A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA 276(14):1141-6.

 

1996

     

Bates CJ, Chen SJ, Macdonald A, Holden R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. Int J Vitam Nutr Res. 1996;66(4):316-21.

 

1996

     

Hammond, B.R., B.R. Wooten, D.M. Snodderly (1996). Cigarette smoking and retinal carotenoids: impliacations for age-related macular degeneration. Vis Res 36(18):3003-3009.

 

1996

     

Yeum KJ, Taylor A, Tang G, Russell RM. Measurement of carotenoids, retinoids, and tocopherols in human lenses. Invest Ophthalmol Vis Sci. 1995 Dec;36(13):2756-61.

 

1995

     

Mares-Perlman JA, Brady WE, Klein R, Klein BE, Bowen P, Stacewicz-Sapuntzakis M, Palta M. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch Ophthalmol. 1995 Dec;113(12):1518-23.

 

1995

     

Hammond, B.R., K. Fuld, J. Curran-Celentano (1995). Macular pigment density in monozygotic twins, Invest Opthalmol Vis Sci 36(12):2531-41.

 

1995

     

Mares-Perlman JA, Brady WE, Klein BE, Klein R, Palta M, Bowen P, Stacewicz-Sapuntzakis M. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Invest Ophthalmol Vis Sci. 1995 Feb;36(2):276-88.

 

1995

     

Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr. 1995 Dec;62(6 Suppl):1448S-1461S.

 

1995

     

Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J, Miller DT, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994 Nov 9;272(18):1413-20.

 

1994

     

Bone RA, Landrum JT, Hime GW, Cains A, Zamor J. Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci. 1993 May;34(6):2033-40.

 

1993

     

(1993). Antioxidant status and neovascular age-related macular degeneration. Eye Disease Case-Control Study Group. Arch Ophthalmol 11(1):104-9.

 

1993

     

Schweitzer D, Guenther S, Scibor M, Hammer M. Spectrometric investigations in ocular hypertension and early stages of primary open angle glaucoma and of low tension glaucoma--multisubstance analysis. Int Ophthalmol. 1992 Sep;16(4-5):251-7.

 

1992

     

Schalch W. Carotenoids in the retina--a review of their possible role in preventing or limiting damage caused by light and oxygen. EXS. 1992;62:280-98.

 

1992

     

Hankinson, S.E., M.J. Stampfer, J.M Seddon, G.A. Colditz, B.Rosner, F.E Speizer, W.C. Willet (1992). Nutrient intake and cataract extraction in women: a prospective study. BMJ 305:335-9.

 

1992

     

Bone RA, Landrum JT. Distribution of macular pigment components, zeaxanthin and lutein, in human retina. Methods Enzymol. 1992;213:360-6.

 

1992

     

Bone RA, Landrum JT, Cains A. Optical density spectra of the macular pigment in vivo and in vitro. Vision Res. 1992 Jan;32(1):105-10.

 

1992

     

Snodderly DM, Handelman GJ, Adler AJ. Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys. Invest Ophthalmol Vis Sci. 1991 Feb;32(2):268-79.

 

1991

     

Handelman GJ, Snodderly DM, Krinsky NI, Russett MD, Adler AJ. Biological control of primate macular pigment. Biochemical and densitometric studies. Invest Ophthalmol Vis Sci. 1991 Feb;32(2):257-67.

 

1991

     

Stark WS, Schilly D, Christianson JS, Bone RA, Landrum JT. Photoreceptor-specific efficiencies of beta-carotene, zeaxanthin and lutein for photopigment formation deduced from receptor mutant Drosophila melanogaster. J Comp Physiol [A]. 1990 Feb;166(4):429-36.

 

1990

     

Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850-5.

 

1988

     

Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):843-9.

 

1988

     

Nussbaum, J., Pruet, R., Delori, F. Historic perspectives. Macular yellow pigmen. The first 200 years. Retina 1981 1:296-310.

 

1981

 

Mission | Links | Search | For More Information | Sitemap | Terms of Use

Copyright 2006 Lutein Information Bureau. All rights reserved.